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While dynorphins have been associated with anxiety and depressive symptoms in certain contexts, some studies indicate that they can enhance serotonin levels, providing potential antidepressant effects [99]

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doi:10.1016/j.clim.2020.108544 76

In the STEP 3 trial of semaglutide combined with intensive lifestyle intervention (30 counseling visits across 68 weeks, including nutrition, physical activity, and other behavioral strategies, plus 8 initial weeks of meal replacements with liquid shakes, meal bars, or portion-controlled meals), individuals experienced a 16% reduction from baseline in body weight (versus 5.7% with intensive lifestyle intervention alone) [178]